Projects and Publication

Here is an overview of the project I have been working on.

Project I

My project focuses on understanding how macrophage and smooth muscle cells in blood vessel interact to promote more fat uptake and turn to become foamy cells

To complete the project, I am using in vitro cell model to assess the cell-cell interactions.

Project II

I am using cell models to evaluate fasting and non-fasting lipid fractions in promoting fat uptake in cells. The goal of my study is to understand different types of lipids in cardiovascular disease lipid risk prediction.

Publication

  1. Xiang, P., Allahverdian, S., Chan, T., Ortega, C., Francis, G. A., & Sahin, B. (2024). Abstract 3046: Macrophage-smooth muscle cell interactions in atherosclerotic foam cell formation. Arteriosclerosis, Thrombosis, and Vascular Biology, (IF=10.5) 44
  2. Besler, K., Baht, V., Xiang, P., Allahverdian, S., Ling, E., Chan, T., & Francis, G. A. (2024). Abstract 1056: Overexpression of lysosomal acid lipase. Arteriosclerosis, Thrombosis, and Vascular Biology, (IF: 10.5), 44 (Paul Dudley White International Scholar Award-Canada)
  3. Allahverdian, S., Xiang, P., Blanchard, V., Sahin, B., Chan, T., & Francis, G. A. (2023). Abstract 14843: Unveiling the phenotype of smooth muscle foam cells in human atherosclerotic lesions: Insights from bulk and single cell RNA sequencing. Circulation (IF:35.5), 148
  4. Xiang, P., Blanchard, V., & Francis, G. A. (2022). Smooth muscle Cell—Macrophage interactions leading to foam cell formation in atherosclerosis: Location, location, location. Frontiers in Physiology (IF:4.8), 13, PMID: 35795646
  5. Xiang, P., Mohamud, Y., & Luo, H. (2021). SNAP47 interacts with ATG14 to promote VP1 conjugation and CVB3 propagation. Cells (IF:5.1), 10, PMID: 34440910
  6. Mohamud, Y., Shi, J., Tang, H., Xiang, P., Xue, Y. C., Liu, H., Ng, C. S., & Luo, H. (2020). Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes. Scientific Reports (IF:4.4), 10, PMID: 33149253
  7. Xue, Y. C., Ng, C. S., Xiang, P., Liu, H., Zhang, K., Mohamud, Y., & Luo, H. (2020). Dysregulation of RNA-binding proteins in amyotrophic lateral sclerosis. Frontiers in Molecular Neuroscience (IF:5.6), 13, PMID: 32547363

Presentation

  1. Xiang, P., Allahverdian, S., Chan, T., Ortega, C., & Sahin, B., Francis, G. A. (2024). Macrophage-smooth muscle cell interactions in atherosclerotic foam cell formation. 2024 American Thoracic Society Vascular Discovery Conference: From Genes to Medicine. (Chicago, Poster)
  2. Xiang, P., Allahverdian, S., Chan, T., Ortega, C., & Sahin, B., Francis, G. A. (2024). Macrophage-smooth muscle cell interactions in atherosclerotic foam cell formation. 2024 HLI Trainee Research Day . (HLI, Poster)
  3. Xiang, P., Allahverdian, S., Chan, T., Ortega, C., & Sahin, B., Francis, G. A. (2024). Understanding Macrophage-Smooth Muscle Cell Interactions In Foam Cell Development In Atherosclerosis. 2024 Faculty of Medicine’s Building the Future-Research Trainee Day and Lecture Series (UBC, Presentation )
  4. Xiang, P., Allahverdian, S., Chan, T., Ortega, C., & Sahin, B., Francis, G. A. (2023). Understanding Macrophage-Smooth Muscle Cell Interactions In Foam Cell Development In Atherosclerosis. 2023 Canadian Lipid and Vascular Summit (Toronto, Presentation)
  5. Xiang, P., Ortega, C., Chan, T., and Francis, G. (2022) Evaluation of Fasting and Non-Fasting Lipoproteins in Cellular Cholesterol Uptake. The 7th annual China-Canada Symposium in Atherosclerosis, Thrombosis and Cardiovascular diseases (Virtual , Poster).
  6. Xiang, P., Ortega, C., Chan, T., and Francis, G. (2022) Evaluation of Fasting and Non-Fasting Lipoproteins in Cellular Cholesterol Uptake 2022 Earl W.Davie Symposium (UBC, Poster).
  7. Xiang, P., Ortega, C., Chan, T., and Francis, G. (2022) Evaluation of Fasting and Non-Fasting Lipoproteins in Cellular Cholesterol Uptake 2022 Canadian Lipid Vascular Summit (Whistler, Poster).